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Search Result

Search Results for " cyclin-dependent kinase 4 "

Targets

CDK

23

Compounds

2

Natural Products

37

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T14916 CDK2-IN-4 CDK
CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM.
T39957 CDK4/6-IN-6 CDK
CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
T9117 BSJ-4-116 CDK , Ligand for E3 Ligase
BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation).
T10736 CDK4/6-IN-2 CDK
CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor (IC50s: 2.7 and 16 nM).
T9078 LY3405105 1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester CDK
LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester) is a novel CDK7 inhibitors.
T10738 Abemaciclib metabolite M20 CDK4/6-IN-4,LSN3106726 CDK
Abemaciclib metabolite M20 (CDK4/6-IN-4) is an active metabolite of Abemaciclib. Abemaciclib metabolite M20 is a selective CDK4/6 inhibitor and can be used for researches on the treatment of cancer.
T14918 CDK9-IN-2 Others , CDK
CDK9-IN-2 is a special CDK9 inhibitor and has an IC50 of 5 nM and 7 nM in A2058 skin cell line (72 hours) and H929 multiple myeloma cell line (72 hours), respectively.
T7167 Purvalanol B NG 95 CDK , Parasite
Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)
T6563 LDC000067 LDC067 Apoptosis , CDK
LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.
T12617L (R)​-​CR8 (R)-CR8,(R)-Isomer,CR8 Apoptosis , CDK
(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.
T14943 CGP60474 VEGFR , CDK , PKC
CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently.
T7426 ALSTERPAULLONE Apoptosis , GSK-3 , CDK
Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec
T23092 NSC 625987 Others
Cyclin-dependent kinase (cdk) 4 inhibitor
T28595 Ro-0505124 Ro0505124,Ro 0505124
Ro-0505124 is a potent, selective and ATP-competitive inhibitor of cyclin-dependent kinase 4 (CDK4).
T71030 3-ATA
3-ATA is a selective cyclin-dependent kinase 4 (Cdk4) inhibitor, attenuating kainic acid-induced apoptosis in neurons.
T79863 Tibremciclib CDK
Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].
TP2133 [Ala92]-p16 (84-103)
Peptide derived from the tumor suppressor protein p16; inhibits cyclin-dependent kinase-4 (cdk4)/cyclin D1 (IC50 ~ 1.5 μM) and binds to cdk6.
T69209 ZK-304709
ZK-304709 is a potent multi-target tumor growth inhibitor with IC50 = nanomolar inhibitory activity to cyclin-dependent kinases 1, 2, 4, 7 and 9, as well as vascular endothelial growth factor receptor tyrosine kinase 1-3...
T60328 CDK4/6-IN-12
CDK4/6-IN-12 is a potent cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. CDK4/6-IN-12 has enzymatic inhibitory activity against CDK4 and CDK6 with IC 50 of 592.3 nM and 3090 nM, respectively. CDK4/6-IN-12 can be used in ...
T73163 CDK7-IN-20
CDK7-IN-20 is a potent, selective, and irreversible inhibitor of Cyclin-Dependent Kinase 7 (CDK7) with an IC50 value of 4 nM, exhibiting over 206-fold selectivity against related kinases CDK1, CDK2, CDK3, CDK5, CDK6, CDK...
T83890 Flavokawain 1i Flavokavain 1i
Flavokawain 1i, a derivative of chalcones flavokawain A, flavokawain B, and flavokawain C, exhibits anticancer and antiviral properties. At a concentration of 30 µM, it suppresses the growth of gefitinib-resistant H1975 ...
T36967 LSN3106729 hydrochloride
LSN3106729 hydrochloride, the metabolite of Abemaciclib , is a CDK inhibitor with antitumor activity. LSN3106729 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1]. [1]. Edward S. Kim, et ...
T36844 Inostamycin A
Inostamycin A is a bacterial metabolite that has been found inStreptomycesand has anticancer activity.1It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50= 0.02 μg/ml in A431 cell membranes)...
Cat No. Product Name Synonyms Targets
TN1299 Desmethylglycitein 6,7,4'-Trihydroxyisoflavone PI3K , CDK , PKC
Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities.
T6S1487 Ginsenoside Rg5 NF-κB , COX , IGF-1R
1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ...

Natural Products

Desmethylglycitein
TN1299
Synonym: 6,7,4'-Trihydroxyisoflavone
Target: PI3K, CDK, PKC
Ginsenoside Rg5
T6S1487
Synonym:
Target: NF-κB, COX, IGF-1R

Recombinant Proteins

Species：
Human (35)
Human,Cynomolgus (1)
Mouse (1)
Expression System：
HEK293 Cells (21)
E. coli (11)
Baculovirus Insect Cells (5)
Tag：
C-His-Avi (6)
Tag Free (5)
C-6xHis (4)
His (4)
C-hFc (3)
His, GST (3)
N-6xHis (3)
C-His (2)
N-hFc (2)
GST (1)
Cat No. Product Name Species Expression System
TMPY-04548 CDK4 Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cel...
TMPJ-00963 CDKN2C Protein, Human, Recombinant (His) Human E. coli
Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) is a member of the INK4 family of cyclin dependent kinase inhibitors. CDKN2C contains 4 ANK repeats and interacts with CDK4 or CDK6. Highest levels of CDKN2C can be found in...
TMPH-01169 CDK4 Protein, Human, Recombinant (His) Human E. coli
CDK4 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01168 CDKN2B Protein, Human, Recombinant (His & Myc) Human E. coli
CDKN2B Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPY-04542 CDK2 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinas...
TMPY-02921 CDK2AP2 Protein, Human, Recombinant (His) Human E. coli
CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including...
TMPJ-00864 VEGF165 Protein, Human, Recombinant Human HEK293 Cells
Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator...
TMPY-00749 FGF-2 Protein, Human, Recombinant Human E. coli
FGF-2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16.5 kDa and the accession number is P09038-4.
TMPK-00823 VEGF165 Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most a...
TMPY-04911 VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated Human,Cynomolgus HEK293 Cells
VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 23.1 kDa and the accession number is P15692-4.
TMPY-04471 APEG1 Protein, Human, Recombinant (His) Human E. coli
Striated muscle preferentially expressed protein kinase, also known as aortic preferentially expressed protein 1, APEG-1, SPEG and KIAA1297, is a protein that belongs to the protein kinase superfamily and CAMK Ser/Thr pr...
TMPY-02893 NT5C3A/NT5C3 Protein, Human, Recombinant Human E. coli
NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded prot...
TMPK-00423 CD45 Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) com...
TMPK-00822 VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most a...
TMPY-04754 CASK Protein, Human, Recombinant Human Baculovirus Insect Cells
CASK Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 102.1 kDa and the accession number is O14936-4.
TMPY-01822 PTK9 Protein, Human, Recombinant (His & GST) Human E. coli
PTK9 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 57 kDa and the accession number is Q12792-4.
TMPK-00424 CD45 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) com...
TMPJ-00782 Amyloid Precursor Protein, Human, Recombinant (hFc) Human HEK293 Cells
Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and...
TMPY-00380 ANTXR2 Protein, Human, Recombinant (hFc) Human HEK293 Cells
ANTXR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57.4 kDa and the accession number is P58335-4.
TMPJ-00410 CD45R0 Protein, Human, Recombinant (His) Human HEK293 Cells
CD45R0 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 80-120 KDa and the accession number is P08575-4.
TMPJ-00233 CD200R1/CRTR2 Protein, Human, Recombinant (His) Human HEK293 Cells
Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain ...
TMPY-01117 MRAP Protein, Human, Recombinant (hFc) Human HEK293 Cells
MRAP (Melanocortin 2 Receptor Accessory Protein) is a Protein Coding gene. This gene encodes a melanocortin receptor-interacting protein. It belongs to the MRAP family. MRAP, which contains a single transmembrane domain,...
TMPY-01033 IL-32 Protein, Human, Recombinant (isoform alpha, His) Human HEK293 Cells
IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathw...
TMPY-05598 Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated Human HEK293 Cells
Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 103.7 kDa and the accession number is P20273-4.
TMPJ-01333 TEM8/ANTXR1 Protein, Human, Recombinant (His) Human HEK293 Cells
Anthrax Toxin Receptor 1 (ANTXR1) is a single-pass type I membrane protein that belongs to the ATR family. ANTXR1 contains one VWFA domain and binds PA through the VWA domain. ANTXR1 is highly expressed in tumor endothel...
TMPY-00711 CD45 Protein, Human, Recombinant (hFc) Human HEK293 Cells
CD45 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.1 kDa and the accession number is P08575-4.
TMPK-00702 ANTXR2 Protein, Human, Recombinant (His) Human HEK293 Cells
The Capillary Morphogenesis Gene 2 (CMG2) gene encodes an Anthrax toxin receptor (ANTXR2),ANTXR2/CMG2 was originally identified as a result of up-regulation during capillary morphogenesis of endothelial cells (ECs) cultu...
TMPY-04565 SRPK3 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Serine / threonine-protein kinase SRPK3, also known as Muscle-specific serine kinase 1, Serine/arginine-rich protein-specific kinase 3, SR-protein-specific kinase 3, Serine / threonine-protein kinase 23, MSSK-1, SRPK3 an...
TMPJ-01188 CORO6 Protein, Human, Recombinant (His) Human E. coli
Coronin 6, a newly identified member of the coronin family, is highly enriched at adult NMJs and regulates AChR clustering via modulating the interaction between receptors and the actin cytoskeletal network. Coronins are...
TMPY-01823 PTK9 Protein, Human, Recombinant Human E. coli
PTK9 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 29 kDa and the accession number is Q12792-4.
TMPY-00225 CLEC9A Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
CLEC9A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.1 kDa and the accession number is Q8BRU4-4.
TMPJ-01256 Caspase-10 Protein, Human, Recombinant (His) Human E. coli
Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granz...
TMPY-04563 CASK Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
CASK Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 130 kDa and the accession number is O14936-4.
TMPY-01933 CHI3L2 Protein, Human, Recombinant (His) Human HEK293 Cells
Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. Its highest expression is in chondrocytes, follo...
TMPY-00119 FLT1 Protein, Human, Recombinant (hFc) Human HEK293 Cells
FLT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number is P17948-4.
TMPK-01356 SIRP alpha V4 Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl...
TMPK-01362 SIRP alpha V4 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl...
CDK4 Protein, Human, Recombinant (GST)
TMPY-04548
Species: Human
Expression System: Baculovirus Insect Cells
CDKN2C Protein, Human, Recombinant (His)
TMPJ-00963
Species: Human
Expression System: E. coli
CDK4 Protein, Human, Recombinant (His)
TMPH-01169
Species: Human
Expression System: E. coli
CDKN2B Protein, Human, Recombinant (His & Myc)
TMPH-01168
Species: Human
Expression System: E. coli
CDK2 Protein, Human, Recombinant (His)
TMPY-04542
Species: Human
Expression System: Baculovirus Insect Cells
CDK2AP2 Protein, Human, Recombinant (His)
TMPY-02921
Species: Human
Expression System: E. coli
VEGF165 Protein, Human, Recombinant
TMPJ-00864
Species: Human
Expression System: HEK293 Cells
FGF-2 Protein, Human, Recombinant
TMPY-00749
Species: Human
Expression System: E. coli
VEGF165 Protein, Human, Recombinant (His & Avi)
TMPK-00823
Species: Human
Expression System: HEK293 Cells
VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-04911
Species: Human,Cynomolgus
Expression System: HEK293 Cells
APEG1 Protein, Human, Recombinant (His)
TMPY-04471
Species: Human
Expression System: E. coli
NT5C3A/NT5C3 Protein, Human, Recombinant
TMPY-02893
Species: Human
Expression System: E. coli
CD45 Protein, Human, Recombinant (His & Avi)
TMPK-00423
Species: Human
Expression System: HEK293 Cells
VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled
TMPK-00822
Species: Human
Expression System: HEK293 Cells
CASK Protein, Human, Recombinant
TMPY-04754
Species: Human
Expression System: Baculovirus Insect Cells
PTK9 Protein, Human, Recombinant (His & GST)
TMPY-01822
Species: Human
Expression System: E. coli
CD45 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00424
Species: Human
Expression System: HEK293 Cells
Amyloid Precursor Protein, Human, Recombinant (hFc)
TMPJ-00782
Species: Human
Expression System: HEK293 Cells
ANTXR2 Protein, Human, Recombinant (hFc)
TMPY-00380
Species: Human
Expression System: HEK293 Cells
CD45R0 Protein, Human, Recombinant (His)
TMPJ-00410
Species: Human
Expression System: HEK293 Cells
CD200R1/CRTR2 Protein, Human, Recombinant (His)
TMPJ-00233
Species: Human
Expression System: HEK293 Cells
MRAP Protein, Human, Recombinant (hFc)
TMPY-01117
Species: Human
Expression System: HEK293 Cells
IL-32 Protein, Human, Recombinant (isoform alpha, His)
TMPY-01033
Species: Human
Expression System: HEK293 Cells
Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPY-05598
Species: Human
Expression System: HEK293 Cells
TEM8/ANTXR1 Protein, Human, Recombinant (His)
TMPJ-01333
Species: Human
Expression System: HEK293 Cells
CD45 Protein, Human, Recombinant (hFc)
TMPY-00711
Species: Human
Expression System: HEK293 Cells
ANTXR2 Protein, Human, Recombinant (His)
TMPK-00702
Species: Human
Expression System: HEK293 Cells
SRPK3 Protein, Human, Recombinant (His & GST)
TMPY-04565
Species: Human
Expression System: Baculovirus Insect Cells
CORO6 Protein, Human, Recombinant (His)
TMPJ-01188
Species: Human
Expression System: E. coli
PTK9 Protein, Human, Recombinant
TMPY-01823
Species: Human
Expression System: E. coli
CLEC9A Protein, Mouse, Recombinant (hFc)
TMPY-00225
Species: Mouse
Expression System: HEK293 Cells
Caspase-10 Protein, Human, Recombinant (His)
TMPJ-01256
Species: Human
Expression System: E. coli
CASK Protein, Human, Recombinant (His & GST)
TMPY-04563
Species: Human
Expression System: Baculovirus Insect Cells
CHI3L2 Protein, Human, Recombinant (His)
TMPY-01933
Species: Human
Expression System: HEK293 Cells
FLT1 Protein, Human, Recombinant (hFc)
TMPY-00119
Species: Human
Expression System: HEK293 Cells
SIRP alpha V4 Protein, Human, Recombinant (His & Avi)
TMPK-01356
Species: Human
Expression System: HEK293 Cells
SIRP alpha V4 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-01362
Species: Human
Expression System: HEK293 Cells
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